How to test the quality of phosphatidylserine liquid?



To test the quality of phosphatidylserine liquid (PS liquid), a variety of quality parameters can be considered. The following are some common tests used to evaluate the quality of PS solution:

Composition and purity:

Thin layer chromatography (TLC): It can help confirm the presence and composition of phosphatidylserine in the liquid.

High-performance liquid chromatography (HPLC): This technique is used to determine the purity and quantitative content of phosphatidylserine in liquid samples.

Mass spectrometry (MS): MS can provide structural information and verify the molecular identity of phosphatidylserine.

Content and concentration:

High-performance liquid chromatography: quantitative analysis Using high-performance liquid chromatography can determine the concentration of phosphatidylserine in liquid samples.

Titration: The content of phosphatidylserine in the liquid can be determined by titration.


Residual solvents: Testing for residual solvents is important to ensure compliance with safety standards. Gas chromatography (GC) or other suitable techniques can be used.

Heavy metals: Atomic absorption spectroscopy (AAS) or inductively coupled plasma mass spectrometry (ICP-MS) can be used to detect and quantify heavy metal contaminants.

Microbial contaminants: Microbial tests, such as total viable count, yeast, and mold, can be performed to assess the microbial quality of PS liquid.

Physical properties:

Appearance: Visually check for changes in color, clarity, or particulate quality of the liquid.

Viscosity: Measuring the viscosity of a PS liquid can provide information about its physical properties.

pH: Testing the pH of a liquid sample can help determine if it is within the acceptable range.

Stability test:

Accelerated stability testing: PS liquid is exposed to high temperature and humidity for a specified period to assess its stability and potential degradation.

Shelf life determination: Long-term stability test under recommended storage conditions to determine the shelf life of PS liquids.

We must develop and validate appropriate testing methods by regulatory requirements and industry standards. In addition, it is recommended to follow good laboratory practices, hire qualified analysts, and use calibrated equipment to perform accurate and reliable tests. Consulting with a reputable laboratory or quality control specialist can help ensure that appropriate testing protocols are followed to assess the quality of PS liquids.