What are the possible problems with caffeic acid application?

Caffeic acid, a naturally occurring compound found in many plants, has potential benefits as an antioxidant and anti-inflammatory agent.However, there are also potential problems with its application, including:

Toxicity: High doses of caffeic acid can be toxic and cause liver damage.

Allergic reactions: Some people may be allergic to caffeic acid and experience allergic reactions such as hives, itching, and difficulty breathing.

Drug interactions: Caffeic acid may interact with certain medications, such as blood thinners, and affect their effectiveness.

Instability: Caffeic acid is unstable and can degrade quickly, which can affect its efficacy and shelf-life.

Limited solubility: Caffeic acid has limited solubility in water, which can make it difficult to formulate and administer in certain applications.